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Morphine injection is used to relieve severe pain that cannot be controlled by the use of alternative pain medications, including oral opioid pain medications. Morphine is in a class of medications called opiate (narcotic) analgesics. It works by changing the way the brain and nervous system respond to pain.

Morphine injection comes as a solution (liquid) to inject intravenously (into a vein) or intramuscularly (into a muscle). Morphine injection also may be injected intrathecally (into the fluid-filled space of the spinal canal) or by epidural injection (injection just outside of the fluid-filled space of the spinal canal) by a doctor in a medical office or clinic. If morphine is injected intravenously or intramuscularly, it is usually injected once every 4 hours as needed. Use morphine injection at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use morphine injection exactly as directed.

Your doctor may adjust your dose of morphine injection during your treatment, depending on how well your pain is controlled and on the side effects that you experience. Talk to your doctor about how you are feeling during your treatment with morphine injection. Tell your doctor if you feel that your pain is not controlled or if your pain increases, becomes worse, or if you have new pain or an increased sensitivity to pain during your treatment with morphine. Do not use more of it or use it more often than prescribed by your doctor.

If you have used morphine injection for longer than a few days, do not stop using it suddenly. If you suddenly stop using morphine injection, you may experience withdrawal symptoms including restlessness; teary eyes; runny nose; yawning; sweating; chills; muscle, back or joint pain; widening of the pupils; irritability; anxiety; weakness; stomach cramps; difficulty falling asleep or staying asleep; nausea; loss of appetite; vomiting; diarrhea; fast breathing; or fast heartbeat. Your doctor will probably decrease your dose gradually.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before using morphine injection,

• tell your doctor and pharmacist if you are allergic to morphine, any other medications, or ingredients in morphine injection. Ask your pharmacist for a list of the ingredients.
• tell your doctor if you have or have ever had any of the conditions mentioned in the IMPORTANT WARNING section, a blockage or narrowing of your stomach or intestines, or paralytic ileus (condition in which digested food does not move through the intestines). Your doctor may tell you not to use morphine.
• tell your doctor if you have or have ever had seizures; low blood pressure; problems urinating; adrenal insufficiency (condition in which the adrenal glands do not produce enough of certain hormones needed for important body functions);or pancreas, gallbladder, heart, liver, or kidney disease.
• tell your doctor if you are breastfeeding. You should not breastfeed while you are using morphine. Morphine can cause shallow breathing, difficulty or noisy breathing, confusion, more than usual sleepiness, trouble breastfeeding, or limpness in breastfed infants.
• you should know that this medication may decrease fertility in men and women. Talk to your doctor about the risks of using morphine.
• if you are having surgery, including dental surgery, tell the doctor or dentist that you are using morphine.
• you should know that this medication may make you drowsy. Do not drive a car or operate machinery until you know how this medication affects you.
• you should know that morphine may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position. To avoid this problem, get out of bed slowly, resting your feet on the floor for a few minutes before standing up.
• you should know that morphine may cause constipation. Talk to your doctor about changing your diet or using other medications to prevent or treat constipation while you are using morphine.