Buy Mesulid Nimesulide 100mg Tablets Online

Mesulid 100mg Tablet is used to treat acute pain, painful osteoarthritis (degeneration of joints) and primary dysmenorrhea (painful menstruation)

Mesulid 100 MG Tablet is a drug used for the management of pain and to treat fever. It is commonly prescribed to acute pain, pain related to menstrual cycles.

Mesulid 100 MG Tablet is a non-steroidal anti-inflammatory medicine (NSAID) that contains Nimesulide as an active ingredient. It is used to treat pain and fever. It provides relief from mild to moderate pain due to menstrual cramps and osteoarthritis.

Composition:

Each tablet contains:

Active substance: nimesulide 100 mg.

Excipients: calcium hydrophosphate 75 mg, microcrystalline cellulose (type

114) 40 mg, corn starch 54 mg, sodium carboxymethyl starch 35 mg, magnesium stearate 3 mg,

silicon dioxide colloidal 2 mg, talc 1 mg.

Description

White with a yellowish tinge round biconvex tablets with a smooth surface.

Pharmacotherapy group: non-steroidal anti-inflammatory drug (NSAID).

ATX code: M01AH17.

Pharmacological properties

Pharmacodynamics

Nonsteroidal anti-inflammatory drug (NSAID) from the class of sulfonanilides. Is

selective competitive inhibitor of cyclooxygenase-2 (COX-2), inhibits the synthesis of prostaglandins in the focus of inflammation. The depressing effect on COX-1 is less pronounced (less often causes side effects associated with inhibition of prostaglandin synthesis in healthy tissues). It has anti-inflammatory, analgesic and pronounced antipyretic effect

action.

Pharmacokinetics

Oral absorption is high (food intake reduces the rate of absorption without affecting its degree). The time to reach the maximum concentration (TCmax) is 1.5 – 2.5 hours. The relationship with plasma proteins is 95%, with red Blood cells-2%, with lipoproteins – 1%, with acidic alpha1 – glycoproteins – 1%. Changing the dose does not affect the degree of binding. The maximum concentration (Cmax) is 3.5 – 6.5 mg/l. The volume of distribution is 0.19 – 0.35 l/kg. Penetrates into the tissues of the female genital organs, where after a single dose, its concentration is about 40% of the concentration in plasma. It penetrates well into the acidic environment of the focus of inflammation (40%), synovial fluid (43%). Easily permeates through gistogematicalkie barriers.

It is metabolized in the liver by tissue monooxygenases. The main metabolite, 4-hydroxynimesulide (25%), has similar pharmacological activity, but due to a decrease in the size of the molecules, it can quickly diffuse along the hydrophobic COX-2 channel to the active binding center of the methyl group. 4-hydroxynimesulide is a water-soluble compound that does not require glutathione and phase II conjugation reactions (sulfation, glucuronidation, and others).

Mesulid 100mg Tablet contains Nimesulide 100mg a pain-relieving medicine used in the treatment of pain such as rheumatoid arthritis, postoperative painful

Mesulid (Nimesulide) 100mg

Nimesulide is a non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties and a specific mode of action. Nimesulide is a sulphonanilide analogue; it is not related to conventional NSAIDs, which usually present a carboxyl or hydroxyl functional group. Nimesulide is proved safe and effective in the treatment of a wide range of inflammatory and painful conditions, including osteoarthritis, extra-articular disorders such as tendinitis and bursitis, post-operative pain, primary dysmenorrhoea.